HCID 86707543, compound → HCID 71004867, compound

Participants

Reaction Steps

tert-butyl (S)-1-((R)-1-(3-(8-(ethylthio)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-ylcarbamate (55 mg, 0.096 mmol) was stirred in TFA for 30 minutes. The reaction was concentrated to dryness, and the residue was diluted in 1 mL of methanol and added dropwise into 4N HCl in ether. The resulting precipitate was filtered and dried under vacuum to yield (S)-1-((R)-1-(3-(8-(ethylthio)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-amine (16 mg, 35% yield) hydrochloride as a solid. LCMS APCI (+) m/z 473 (M+H).

Provenance & Evidence