Hydrochloric Acid → HCID 86707547, compound

Participants

Reaction Steps

To a solution of (3R,4R)-tert-butyl 3-(benzyloxycarbonylamino)-4-methoxypyrrolidine-1-carboxylate (2.90 g, 8.28 mmol) in DCM (20 mL) was added 4 N HCl (20.69 mL, 82.76 mmol) in dioxane. The reaction mixture was stirred at ambient temperature for 2 hours. The solvent was removed under reduced pressure. Saturated bicarbonate (20 mL) and DCM (50 mL) were added. The organic layer was separated, dried (sodium sulfate), filtered and concentrated under reduced pressure to give benzyl (3R,4R)-4-methoxypyrrolidin-3-ylcarbamate (2.0 g, 96.6%) as oil.

Provenance & Evidence