Hydrochloric Acid → HCID 70984649, compound

Participants

Reaction Steps

To a solution of tert-butyl (S)-1-((R)-1-(3-(8-tert-butylquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate (0.197 g, 0.383 mmol) in DCM (1 mL) was added 4 N HCl (1.92 mL, 7.66 mmol) in IPA. The mixture was stirred at ambient temperature for 1 hour. The solvent was removed under reduced pressure and ether (5 mL) was added. The suspension was stirred at ambient temperature for 10 minutes and the solid formed was collected by filtration to give (S)-1-((R)-1-(3-(8-tert-butylquinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl) pyrrolidin-3-amine (0.186 g, 92.8%) as solid. LCMS APCI (+) m/z 415 (M+H).

Provenance & Evidence