HCID 86707553, compound → HCID 70984236, compound

Participants

Reaction Steps

A solution of tert-butyl (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(oxetan-3-yl)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-ylcarbamate (0.015 g, 0.026 mmol) in formic acid (0.51 ml, 13.2 mmol) was stirred at ambient temperature for 10 hours. The solvent was removed under reduced pressure to give (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-(oxetan-3-yl)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine (0.012 g, 0.026 mmol, 97% yield) as a formic acid salt. LCMS APCI (+) m/z 469 (M+H).

Provenance & Evidence