4-Triisopropylsilanyloxymethyl-benzoic acid → N-Methoxy-N-methyl-4-triisopropylsilanyloxymethyl-benzamide

HRID 33909Notes

Reaction equation

HRID 33909 reaction equation
C(O[C:9]1[CH:20]=[CH:19][C:12]([C:13]([N:15]([O:17][CH3:18])[CH3:16])=[O:14])=[CH:11][CH:10]=1)C1C=CC=CC=1.[CH:21]([Si:24]([CH:39]([CH3:41])[CH3:40])([CH:36]([CH3:38])[CH3:37])[O:25][CH2:26]C1C=CC(C(O)=O)=CC=1)([CH3:23])[CH3:22]>>[CH3:18][O:17][N:15]([CH3:16])[C:13](=[O:14])[C:12]1[CH:11]=[CH:10][C:9]([CH2:26][O:25][Si:24]([CH:21]([CH3:23])[CH3:22])([CH:39]([CH3:41])[CH3:40])[CH:36]([CH3:38])[CH3:37])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 112205674-Triisopropylsilanyloxymethyl-benzoic acidHCID 113117774-(Benzyloxy)-N-methoxy-N-methylbenzamide

Product 1

HCID 86249259N-Methoxy-N-methyl-4-triisopropylsilanyloxymethyl-benzamide

Procedure

Following the procedure for the preparation of 4-benzyloxy-N-methoxy-N-methyl-benzamide but substituting 4-Triisopropylsilanyloxymethyl-benzoic acid provided the title compound. MS: (M+H m/z=352.1).

Sources & evidence

ORD record
ord-c508a9a59f9e4fb5a7685d1240812bf7
Source dataset
uspto-grants-2008_09
Patent number
US07429665B2

Reaction notes

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