Water → HCID 86653068, compound

Participants

Reaction Steps

626 mg (3.30 mmol) of Sn(II)Cl2 were initially charged in 5 ml of ethanol, and 350 mg (0.83 mmol) of (2E)-3-(3-nitrophenyl)-N-{2,2,2-trifluoro-1-[3-(trifluoromethyl)phenyl]ethyl}-acrylamide from Example 3, Stage 1 were added. The reaction solution was stirred at reflux temperature for 1 hour, cooled and admixed with 50 ml of water. While cooling with ice, the pH was adjusted to 9 with concentrated sodium hydroxide solution and the mixture was then extracted with dichloromethane. The organic phase was dried with sodium sulphate, the solvent distilled off under reduced pressure and the residue stirred with diisopropyl ether.

Provenance & Evidence