4-[3-(4-Benzyloxy-phenyl)-1-methyl-1H-pyrazol-4-yl]-pyridine → 4-[1-Methyl-3-(4-triisopropylsilanyloxymethyl-phenyl)-1H-pyrazol-4-yl]-pyridine

HRID 33911Notes

Reaction equation

C(O[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:19]([C:20]3[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=3)=[CH:18][N:17]([CH3:26])[N:16]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.N1C=CC(CC(C2C=CC([CH2:42][O:43][Si:44]([CH:51]([CH3:53])[CH3:52])([CH:48]([CH3:50])[CH3:49])[CH:45]([CH3:47])[CH3:46])=CC=2)=O)=CC=1>>[CH3:26][N:17]1[CH:18]=[C:19]([C:20]2[CH:21]=[CH:22][N:23]=[CH:24][CH:25]=2)[C:15]([C:12]2[CH:11]=[CH:10][C:9]([CH2:42][O:43][Si:44]([CH:45]([CH3:47])[CH3:46])([CH:51]([CH3:53])[CH3:52])[CH:48]([CH3:50])[CH3:49])=[CH:14][CH:13]=2)=[N:16]1

Participants

Reactant 2

HCID 442349314-[3-(4-Benzyloxy-phenyl)-1-methyl-1H-pyrazol-4-yl]-pyridine

HCID 685761892-Pyridin-4-yl-1-(4-triisopropylsilanyloxymethyl-phenyl)-ethanone

Product 1

HCID 685782264-[1-Methyl-3-(4-triisopropylsilanyloxymethyl-phenyl)-1H-pyrazol-4-yl]-pyridine

Procedure

Following the procedure for the preparation of 4-[3-(4-Benzyloxy-phenyl)-1-methyl-1H-pyrazol-4-yl]-pyridine but substituting 2-Pyridin-4-yl-1-(4-triisopropylsilanyloxymethyl-phenyl)-ethanone provided the title compound. MS: (M+H m/z=422.2).

Sources & evidence

ORD record: ord-222d021277a344fdb4d2a72a8bd1f33d
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429665B2

Reaction notes

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