HCID 88851236, compound → HCID 178506438, compound

HRID 339143Notes

Reaction equation

[Na+].[F:2][C:3]([F:19])([S:15]([O-:18])(=[O:17])=[O:16])[CH2:4][O:5][CH2:6][CH:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.FC(F)(F)S([O-])(=O)=O.[C:28]1([SH+:34]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)(C)[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:28]1([SH+:34]([C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)([F:2])[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.[F:19][C:3]([F:2])([S:15]([O-:18])(=[O:17])=[O:16])[CH2:4][O:5][CH2:6][CH:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 88851236HCID 88851236, compound

HCID 178504119HCID 178504119, compound

Product 1

HCID 178506438HCID 178506438, compound

Procedure

As shown in the following reaction scheme (2-2), the 1,1-difluoro-2-(2-hydroxy-2-phenylethoxy)ethanesulfonic acid sodium salt produced in Step 1 was allowed to react with diphenyl methylphenyl sulfonium trifluoromethane sulfonate in the same manner as in Step 2 of Synthesis Example 1, and thus 1,1-difluoro-2-(2-hydroxy-2-phenyl-ethoxy)-ethanesulfonic acid diphenyl fluorophenyl sulfonium salt was obtained. Its structure was confirmed by 1H-NMR.

Workup

customAs shown in the following reaction scheme (2-2)

Sources & evidence

ORD record: ord-85b36ae778c145228105bd9d81d9fec5
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889901B2

Reaction notes

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