HCID 88851006, compound → HCID 178506439, compound

HRID 339144Notes

Reaction equation

HRID 339144 reaction equation
[Na+].[C:2]12([CH2:12][CH:13]([OH:24])[CH2:14][O:15][CH2:16][C:17]([F:23])([F:22])[S:18]([O-:21])(=[O:20])=[O:19])[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH2:3]1)[CH2:9]2.FC(F)(F)S([O-])(=O)=O.[C:33]1([SH+:39]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)(C)[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[C:33]1([SH+:39]([C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)([F:22])[C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.[C:2]12([CH2:12][CH:13]([OH:24])[CH2:14][O:15][CH2:16][C:17]([F:22])([F:23])[S:18]([O-:21])(=[O:20])=[O:19])[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([CH2:5]3)[CH2:3]1)[CH2:9]2

Participants

3

Reactant 2

HCID 88851006HCID 88851006, compoundHCID 178504119HCID 178504119, compound

Product 1

HCID 178506439HCID 178506439, compound

Procedure

As shown in the following reaction scheme (4-2), the 2-(3-adamantan-1-yl-2-hydroxypropoxy)-1,1-difluoroethanesulfonic acid sodium salt produced in Step 1 was allowed to react with diphenyl methylphenyl sulfonium trifluoromethane sulfonate in the same manner as in Step 2 of Synthesis Example 1. Thus, 2-(3-adamantan-1-yl-2-hydroxypropoxy)-1,1-difluoroethanesulfonic acid diphenyl fluorophenyl sulfonium salt was obtained. Its structure was confirmed by 1H-NMR.

Workup

  1. customAs shown in the following reaction scheme (4-2)

Sources & evidence

ORD record
ord-f2b4fdc6a95048dbb9fbc29aba7f595e
Source dataset
uspto-grants-2014_11
Patent number
US08889901B2

Reaction notes

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