Dimethyl Sulfoxide → (S)-2-tert-Butyl 7-methyl 3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate

Participants

Reaction Conditions

Reaction Steps

A 20 mL scintillation vial with a septum top was charged sequentially with (S)-tert-butyl 3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-7-(((trifluoromethyl)sulfonyl)oxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1.39 g, 2.50 mmol), Pd(OAc)2 (0.028 g, 0.12 mmol), and 1,3-bis(diphenylphosphino)propane (0.052 g, 0.12 mmol). DMSO (3.7 mL), MeOH (2.5 mL), and Et3N (0.77 mL, 5.50 mmol) were then added, and the reaction mixture was stirred for 5 min. A CO balloon was then used to purge the reaction vial, turning the solution black. The reaction was topped with the CO balloon and heated to 70° C. for 12 h. The reaction mixture was then filtered through an ACRODISC®, and the filtrate was poured into a separatory funnel containing EtOAc and sat. aq. NH4Cl solution. The aqueous layer was extracted with EtOAc (2×). The combined organic layers were washed with sat. NaCl (2×), dried over MgSO4, filtered and concentrated in vacuo. The crude oil was purified by flash column chromatography (gradient elution from 0 to 50% EtOAc/hexanes) to afford the title compound (1.06 g, 2.28 mmol, 91%) as a light yellow solid. MS (ESI+) m/z 465.2 (M+H)+.

Provenance & Evidence