反应详情

A solution of (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylate (1.21 g, 2.09 mmol) in CH2Cl2 (13.9 mL) was charged with TFA (3.49 mL) at room temperature. After 40 min, the reaction mixture was quenched carefully with sat. NaHCO3 and then extracted with EtOAc (3×). The combined extracts were washed with sat. NaCl, dried over MgSO4, filtered and concentrated in vacuo to afford the title compound (0.97 g, 2.02 mmol, 97%) as a light yellow foam, which was used without further purification. MS (ESI+) m/z 478.2 (M+H)+.

1. customthe reaction mixture was quenched carefully with sat. NaHCO3
2. extractionextracted with EtOAc (3×)
3. washThe combined extracts were washed with sat. NaCl
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo