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HRID339239

反应详情

EQUATION

反应方程式

HRID 339239 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H](C(=O)N[C@H](C(=O)N1Cc2cc(C(=O)O)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C)N(C)C(=O)OC(C)(C)C
HCID86705870

未命名化合物

结构：COC(=O)[C@@H]1C[C@H](NC(=O)c2ccc3c(c2)CN(C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)[C@H](C(=O)N[C@@H]2CCCc4ccccc42)C3)CN1C(=O)OCc1ccccc1
HCID86705871

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](C(=O)N[C@H](C(=O)N1Cc2cc(C(=O)N[C@H]3C[C@@H](C(=O)O)N(C(=O)OCc4ccccc4)C3)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C)N(C)C(=O)OC(C)(C)C
HCID86705872

未命名化合物

收率 99.5%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Compound K, (2S,4S)-1-benzyl 2-methyl 4-((S)-2-((S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-3,3-dimethylbutanoyl)-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamido)pyrrolidine-1,2-dicarboxylate (192 mg, 0.21 mmol) was converted to the title compound (187 mg, 99%). MS (ESI+) m/z 895.5 (M+H)+.