HCID 86705873, compound → HCID 72705162, compound

Participants

Reaction Steps

To a 50 mL pressure flask containing Pd(OH)2 on carbon (2 mg, 0.02 mmol) was added a solution of (2S,4S)-benzyl 4-((S)-2-((S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-3,3-dimethylbutanoyl)-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamido)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidine-1-carboxylate (177 mg, 0.17 mmol) in MeOH (5.8 mL). The resulting reaction mixture was stirred under H2 at 15 psi for 2 h and then filtered through a pad of CELITE® washing with EtOAc. The filtrate was concentrated in vacuo, and the resulting crude oil was purified using flash column chromatography (gradient elution from 0 to 10% NH3/MeOH/CH2Cl2) to give the title compound (80 mg, 52%) as a colorless oil. MS (ESI+) m/z 890.6 (M+H)+.

Provenance & Evidence