HRID339246

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7058072

(-)-1,2,3,4-Tetrahydro-1-naphthylamine

C10H13N

结构：O=C1C[C@@H](C(=O)O)N(C(=O)OCc2ccccc2)C1

HCID11076282

N-Carbobenzyloxy-4-keto-L-proline

C13H13NO5

结构：CC(C)(C)OC(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21

HCID86705863

未命名化合物

PRODUCTS

生成物

结构：O=C1C[C@@H](C(=O)N[C@@H]2CCCc3ccccc32)N(C(=O)OCc2ccccc2)C1

HCID86705881

未命名化合物

收率 100%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Compound D of Example 1, (S)-1-((benzyloxy)carbonyl)-4-oxopyrrolidine-2-carboxylic acid (Aldrich, 4.00 g, 15.2 mmol) and (R)-1,2,3,4-tetrahydronaphthalen-1-amine (Alfa Aesar, 2.23 mL, 15.2 mmol) were converted to the title compound (5.96 g, 100%). MS (ESI+) m/z 393.1 (M+H)+.