HCID 72705162, compound → HCID 117710490, compound

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Compound G of Example 1, (S)-tert-butyl 7-((3R,5S)-1-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3,3-dimethylbutanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (97 mg, 0.10 mmol) was converted to the title compound (85 mg, 97%). MS (ESI+) m/z 884.4 (M+H)+.

Provenance & Evidence