HCID 72705162, compound → HCID 117710426, compound

HRID 339251Notes

Reaction equation

HRID 339251 reaction equation
CC(C)(C)[C@H](NC(=O)[C@@H](NC)C)C(N1[C@H](C(N[C@H]2C3C(=CC=CC=3)CCC2)=O)CC2C(=CC(C(N[C@H]3C[C@@H](C(=O)N[C@H]4C5C(=CC=CC=5)CCC4)N(C(=O)[C@@H](NC(=O)[C@@H](NC)C)C(C)(C)C)C3)=O)=CC=2)C1)=O.[C@H:73]1([NH:83][C:84]([C@H:86]2[N:90](C(OCC3C=CC=CC=3)=O)[CH2:89][C:88]([C:101]([O:103][CH3:104])=[O:102])=[CH:87]2)=[O:85])[C:82]2[C:77](=[CH:78][CH:79]=[CH:80][CH:81]=2)[CH2:76][CH2:75][CH2:74]1>>[C@H:73]1([NH:83][C:84]([C@H:86]2[NH:90][CH2:89][C@@H:88]([C:101]([O:103][CH3:104])=[O:102])[CH2:87]2)=[O:85])[C:82]2[C:77](=[CH:78][CH:79]=[CH:80][CH:81]=2)[CH2:76][CH2:75][CH2:74]1

Participants

3

Reactant 2

HCID 72705162HCID 72705162, compoundHCID 117710476HCID 117710476, compound

Product 1

HCID 117710426HCID 117710426, compoundYield 97%

Procedure

Following a procedure analogous to that for the synthesis of Compound T of Example 1, (S)-1-benzyl 3-methyl 5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1H-pyrrole-1,3(2H,5H)-dicarboxylate (156 mg, 0.36 mmol) was converted to the title compound (105 mg, 97%). MS (ESI+) m/z 303.2 (M+H)+.

Sources & evidence

ORD record
ord-8ea35daef0014ff591bdb9e86c6e04de
Source dataset
uspto-grants-2014_11
Patent number
US08889712B2

Reaction notes

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