(S)-tert-Butyl 4-oxo-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidine-1-carboxylate → (S)-tert-Butyl 2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-4-(((trifluoromethyl)sulfonyl)oxy)-2,5-dihydro-1H-pyrrole-1-carboxylate

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Compound B of Example 22, (S)-tert-butyl 4-oxo-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidine-1-carboxylate (3.38 g, 9.43 mmol) was converted to the title compound (2.82 g, 61%). MS (ESI+) m/z 491.2 (M+H)+.

Provenance & Evidence