HRID339264

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@@H](C(=O)N[C@H](C(=O)N1Cc2cc(C(=O)O)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc21)C(C)(C)C)N(C)C(=O)OC(C)(C)C

HCID86705870

未命名化合物

结构：COC(=O)[C@@H]1Cc2ccc([C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)OC(C)(C)C)C3)cc2CN1C(=O)OC(C)(C)C

HCID86705905

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1Cc2cc([C@H]3C[C@@H](C(=O)N[C@@H]4CCCc5ccccc54)N(C(=O)OC(C)(C)C)C3)ccc2C[C@H]1C(=O)O

HCID86705904

未命名化合物

收率 94%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Compound K of Example 1, (S)-2-tert-butyl 3-methyl 7-((3R,5S)-1-(tert-butoxycarbonyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate (650 mg, 1.03 mmol) was converted to the title compound (599 mg, 94%). MS (ESI+) m/z 620.5 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cb45a96eb198414ca67a5f4ae3bb32c0
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08889712B2
来源说明: uspto-grants-2014_11

反应 SMILES

C(OC(N(C)[C@@H](C)C(N[C@@H](C(C)(C)C)C(N1[C@H](C(=O)N[C@H]2C3C(=CC=CC=3)CCC2)CC2C(=CC(C(O)=O)=CC=2)C1)=O)=O)=O)(C)(C)C.[C:48]([O:52][C:53]([N:55]1[C@H:59]([C:60](=[O:72])[NH:61][C@H:62]2[C:71]3[C:66](=[CH:67][CH:68]=[CH:69][CH:70]=3)[CH2:65][CH2:64][CH2:63]2)[CH2:58][C@H:57]([C:73]2[CH:82]=[C:81]3[C:76]([CH2:77][C@@H:78]([C:90]([O:92]C)=[O:91])[N:79]([C:83]([O:85][C:86]([CH3:89])([CH3:88])[CH3:87])=[O:84])[CH2:80]3)=[CH:75][CH:74]=2)[CH2:56]1)=[O:54])([CH3:51])([CH3:50])[CH3:49]>>[C:86]([O:85][C:83]([N:79]1[C@H:78]([C:90]([OH:92])=[O:91])[CH2:77][C:76]2[C:81](=[CH:82][C:73]([C@H:57]3[CH2:58][C@@H:59]([C:60](=[O:72])[NH:61][C@H:62]4[C:71]5[C:66](=[CH:67][CH:68]=[CH:69][CH:70]=5)[CH2:65][CH2:64][CH2:63]4)[N:55]([C:53]([O:52][C:48]([CH3:51])([CH3:50])[CH3:49])=[O:54])[CH2:56]3)=[CH:74][CH:75]=2)[CH2:80]1)=[O:84])([CH3:89])([CH3:88])[CH3:87]