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HRID339281

反应详情

EQUATION

反应方程式

HRID 339281 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)[C@@H]1C=C(OS(=O)(=O)C(F)(F)F)CN1C(=O)OC(C)(C)C
HCID11773246

(S)-1-tert-Butyl 2-methyl 4-(((trifluoromethyl)sulfonyl)oxy)-1H-pyrrole-1,2(2H,5H)-dicarboxylate

C12H16F3NO7S

结构：COC(=O)[C@@H]1Cc2ccc(B3OC(C)(C)C(C)(C)O3)cc2CN1C(=O)OC(C)(C)C
HCID86705903

未命名化合物

结构：C[C@@H](C(=O)N[C@H](C(=O)N1C[C@@H](c2ccc3c(c2)CN(C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)[C@H](C(=O)N[C@@H]2CCCc4ccccc42)C3)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)(C)C)N(C)C(=O)OC(C)(C)C
HCID86705917

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1C=C(c2ccc3c(c2)CN(C(=O)OC(C)(C)C)[C@H](C(=O)OC)C3)CN1C(=O)OC(C)(C)C
HCID86705924

未命名化合物

收率 70%

PROCEDURE

实验过程

Following a procedure analogous to that for the synthesis of Compound D of Example 22, (S)-1-tert-butyl 2-methyl 4-(((trifluoromethyl)sulfonyl)oxy)-1H-pyrrole-1,2(2H,5H)-dicarboxylate (585 mg, 1.56 mmol) and (S)-2-tert-butyl 3-methyl 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate (650 mg, 1.56 mmol) were converted to the title compound (563 mg, 70%). MS (ESI+) m/z 517.4 (M+H)+.