(S)-2-((S)-2-((S)-2-((tert-Butoxycarbonyl)(methyl)amino)propanamido)-3,3-dimethylbutanoyl)-3-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid → (S)-2-(tert-Butoxycarbonyl)-7-((3R,5S)-1-(tert-butoxycarbonyl)-5-carboxypyrrolidin-3-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Participants

Reaction Steps

Following a procedure analogous to that for the synthesis of Compound K of Example 1, (3S)-2-tert-butyl 3-methyl 7-((5S)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)pyrrolidin-3-yl)-3,4-dihydroisoquinoline-2,3(1H)-dicarboxylate (500 mg, 0.96 mmol) was converted to the title compound (450 mg, 95%). MS (ESI+) m/z 491.4 (M+H)+.

Provenance & Evidence