Methyl iodide → 4-(3-Acetylphenyl)amino-2-amino-1,6-dimethylpyrimidinium iodide

HRID 3393Notes

Reaction equation

HRID 3393 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]2[CH:16]=[C:15]([CH3:17])[N:14]=[C:13]([NH2:18])[N:12]=2)[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[CH3:19][I:20]>CC(C)=O>[I-:20].[C:1]([C:4]1[CH:5]=[C:6]([NH:10][C:11]2[CH:16]=[C:15]([CH3:17])[N+:14]([CH3:19])=[C:13]([NH2:18])[N:12]=2)[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 133110Cni H1594

Product 1

HCID 120932594-(3-Acetylphenyl)amino-2-amino-1,6-dimethylpyrimidinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Compound No. 14: 4-(3-acetylphenyl)amino-2-amino-6methylpyrimidine, Compound No. 15, (0.968 g) was suspended in acetone (5 mL) containing methyl iodide (2 mL) was heated at reflux for 48 hr. Filtration after cooling gave 0.657 g of 4-(3-acetylphenyl)amino-2-amino-1,6-dimethylpyrimidinium iodide as a white powder, mp 238°-40° C.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 48 hr
  3. filtrationFiltration
  4. temperatureafter cooling

Sources & evidence

ORD record
ord-74a2ccfcddee49eb8680c2a9e7272626
Source dataset
uspto-grants-1998_03
Patent number
US05733932

Reaction notes

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