D-Leucine, methyl ester → (R)-methyl 2-(2-methoxy-4-(methylthio)benzamido)-4-methylpentanoate

HRID 339364Notes

Reaction equation

HRID 339364 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=O.[CH3:14][O:15][C:16](=[O:23])[C@@H:17]([CH2:19][CH:20]([CH3:22])[CH3:21])[NH2:18]>>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([NH:18][C@H:17]([CH2:19][CH:20]([CH3:22])[CH3:21])[C:16]([O:15][CH3:14])=[O:23])=[O:7]

Participants

3

Reactant 2

HCID 89967D-Leucine, methyl esterHCID 6433294-(Methylthio)-o-anisic acid

Product 1

HCID 40433016(R)-methyl 2-(2-methoxy-4-(methylthio)benzamido)-4-methylpentanoate

Procedure

Prepared in a similar manner to example 4 using 2-methoxy-4-(methylthio)benzoic acid and D-leucine methyl ester. MS (M+H, 326).

Sources & evidence

ORD record
ord-f60f8871c6ca42cda014ce37e33bff69
Source dataset
uspto-grants-2014_11
Patent number
US08895050B2

Reaction notes

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