D-Leucine, methyl ester → HCID 57527860, compound

HRID 339379Notes

Reaction equation

HRID 339379 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:12][CH3:13])[N:11]=1)[C:6]([OH:8])=O.[CH3:14][O:15][C:16](=[O:23])[C@@H:17]([CH2:19][CH:20]([CH3:22])[CH3:21])[NH2:18]>>[CH3:13][O:12][C:10]1[CH:9]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[N:11]=1)[C:6]([NH:18][C@H:17]([CH2:19][CH:20]([CH3:22])[CH3:21])[C:16]([O:15][CH3:14])=[O:23])=[O:8]

Participants

3

Reactant 2

HCID 89967D-Leucine, methyl esterHCID 2357522,6-Dimethoxyisonicotinic acid

Product 1

HCID 57527860HCID 57527860, compound

Procedure

Prepared in a similar manner to example 4 using 2,6-Dimethoxy-isonicotinic acid and D-leucine methyl ester. 1H NMR (500 MHz, CDCl3): δ 0.92 (d, 3H, J=7.27 Hz), 0.93 (d, 3H, J=7.26 Hz), 1.41-1.58 (m, 8H), 3.95 (s, 3H), 4.08 (s, 3H), 4.15 (m, 1H), 6.43 (d, 1H, J=8.32 Hz), 7.47 (m, broad, 1H), 8.41 (d, 1H, J=8.34 Hz). MS (M+H; 311).

Sources & evidence

ORD record
ord-afbdb716dcbb49968d59db1cfc8979b1
Source dataset
uspto-grants-2014_11
Patent number
US08895050B2

Reaction notes

Loading…