2-Pyridineethanamine → HCID 52185469, compound

HRID 339408Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH2:9].[CH2:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[O:21])=[CH:15][CH:14]=1)[CH3:11]>>[CH2:10]([O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20]([NH:9][CH2:8][CH2:7][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=2)=[O:21])=[CH:15][CH:14]=1)[CH3:11]

Participants

Reactant 2

HCID 759192-Pyridineethanamine

HCID 122887Benzene, 1-ethoxy-4-isocyanato-

Product 1

HCID 52185469HCID 52185469, compoundYield 95%

Procedure

Prepared in a similar manner to example 158 using 2-(pyridine-2-yl) ethanamine and 1-ethoxy-4-isocyanatobenzene. Yield: 95%. mp: 163-164° C. 1H NMR (500 MHz, CDCl3): δ 1.43 (t, 3H), 3.03 (t, 2H), 3.68 (t, 2H), 4.03 (q, 2H), 5.69 (br s, 1H), 6.45 (br s, 1H), 6.84 (m, 2H), 7.14 (m, 3H), 7.20 (d, 1H), 7.64 (dt, 1H), 8.43 (dd, 1H). MS (M+H, 286).

Sources & evidence

ORD record: ord-6fbabbc5b90f4dde8bd1898deae81717
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08895050B2

Reaction notes

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