反应详情

tert-Butyl N-[(1R)-2-(benzyloxy)-1-(hydroxymethyl)ethyl]carbamate (1.2 g, 4.3 mmole) was dissolved in CH2Cl2 (40 mL). Dess-Martin periodinane (2.4 g, 5.5 mmole) was added. The solution was stirred for 2 h at room temperature and then quenched with Na2S2O3 and saturated bicarbonate solution. After extracting with CH2Cl2, the organic layer was dried over MgSO4, filtered, and concentrated by rotary evaporation. Purification by chromatography (silica, 4/1: Hexane/EtOAc, Rf=0.4) afforded (S)-tert-butyl 1-(benzyloxy)-3-oxopropan-2-ylcarbamate as a white solid (1.1 g, 96%).

1. customquenched with Na2S2O3 and saturated bicarbonate solution
2. extractionAfter extracting with CH2Cl2
3. dry with materialthe organic layer was dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated by rotary evaporation
6. customPurification by chromatography (silica, 4/1: Hexane/EtOAc, Rf=0.4)