Benzothiazole → HCID 178511489, compound

Participants

Reaction Conditions

Reaction Steps

In this reaction, a thiobenzamide is converted to a benzothiazole in the presence of potassium ferricyanide. In a typical reaction, a thiobenzamide (1 equiv) is dissolved in NaOH (1.5 M, 39 equiv.) and the solution cooled to 5° C. with ice. Potassium ferricyanide in water (20%, 15 vol) is added and the reaction stirred at it for 18 h. The mixture is filtered and the solid washed with H2O. The solid is dissolved in DCM (20 vol), dried (Na2SO4) and the solvent removed under reduced pressure to give the crude benzothiazole product. Column chromatography may be carried out in order to obtain the pure target material.

Provenance & Evidence