HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous chloride dihydrate → 2-(4-Amino-3-methoxyphenyl)-6-methoxybenzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | Tetrahydrofuran hexane | HCID 21883165 | — |
| Reactant | 2-(3-Methoxy-4-nitrophenyl)-6-methoxybenzothiazole | HCID 67236825 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(4-Amino-3-methoxyphenyl)-6-methoxybenzothiazole | HCID 67238300 | 91.8% |
Reaction Steps
Prepared as described in the Nitro Reduction section using 2-(3-methoxy-4-nitrophenyl)-6-methoxybenzothiazole (0.5 g, 1.56 mmol) and tin (II) dichloride dihydrate (2.61 g, 11.58 mmol) in EtOH (35 ml) to give the title compound (0.41 g, 91%) as a pale orange solid after work-up and flash chromatography (2:1 Hexane/THF).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895313B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d56b22108b3d4b9e9bdc3c3faaf9660e |
| Source note | uspto-grants-2014_11 |