HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 4-(1,3-Benzothiazol-2-yl)-3-[2-(dimethylamino)ethoxy]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | 2-[2-(1,3-benzothiazol-2-yl)-5-nitrophenoxy]-N,N-dimethylethanamine | HCID 67312262 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(1,3-Benzothiazol-2-yl)-3-[2-(dimethylamino)ethoxy]aniline | HCID 67236657 | 76% |
Reaction Steps
Prepared as described in the Nitro Reduction section using 2-[2-(1,3-benzothiazol-2-yl)-5-nitrophenoxy]-N,N-dimethylethanamine (0.073 g, 0.21 mmol) and tin (II) dichloride dihydrate (0.38 g, 1.7 mmol) in EtOH (7 ml) to give the title compound (0.05 g, 75%) as a cream-coloured solid after work-up and flash chromatography (MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895313B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f7d3c7909bc745f19c42e2bf41902b4c |
| Source note | uspto-grants-2014_11 |