HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 4-(1,3-Benzothiazol-2-yl)-3-[2-{2-(2-methoxyethoxy)ethoxy}ethoxy]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | 2-[2-{2-(2-(2-Methoxyethoxy)ethoxy)ethoxy}-4-nitrophenyl]-1,3-benzothiazole | HCID 67237521 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(1,3-Benzothiazol-2-yl)-3-[2-{2-(2-methoxyethoxy)ethoxy}ethoxy]aniline | HCID 67237179 | 93% |
Reaction Steps
Prepared as described in the Nitro Reduction section using 2-[2-{2-(2-(2-methoxyethoxy)ethoxy)ethoxy}-4-nitrophenyl]-1,3-benzothiazole (0.15 g, 0.36 mmol) and tin (II) dichloride dihydrate (0.65 g, 2.87 mmol) in EtOH (12 to give the title compound (0.13 g, 92%) as a viscous, yellow oil after work-up and flash chromatography (EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895313B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-2cd4528cfe24485ba3f1531b1734826e |
| Source note | uspto-grants-2014_11 |