HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → HCID 67312782, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Dichloromethane ethylacetate | HCID 21226138 | — |
| Reactant | HCID 67313401 | HCID 67313401 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 67312782 | HCID 67312782 | 37% |
Reaction Steps
Prepared as described in the Amination section using sodium cyanoborohydride (66 mg, 1.05 mmol), 4-amino-2-trifluoromethyl-N-[4-(6-methoxybenzothiazol-2-yl)-phenyl]-benzamide (100 mg, 0.226 mmol) and paraformaldehyde (63 mg, 2.11 mmol) in AcOH (3 ml) to give the title compound (39 mg, 37%) as a colourless solid after work-up and flash chromatography (20:1 DCM/EtOAc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895313B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-0ec6fd05c4af47f68f86dc258203939a |
| Source note | uspto-grants-2014_11 |