6-Bromonicotinic acid → HCID 87351673, compound

Participants

Reaction Steps

To a solution of 6-bromonicotinic acid (0.16 g, 0.78 mmol) in dry THF (5 ml) was added under an atmosphere of argon 1,1′-carbonyldiimidazole (0.13 g, 0.78 mmol) and the reaction mixture stirred at room temperature for 5 h. To the reaction mixture was added 2-(4-aminophenyl)-6-methoxybenzothiazole (0.2 g, 0.78 mmol) over 2 mins, stirring continued at room temperature for 1 h, then heated under reflux for 18 h. After cooling to room temperature, the reaction mixture was diluted with Et2O (30 ml) and the precipitate was collected by filtration, washed with Et2O (50 ml) and dried under high vacuum to give the title compound (0.101 g, 29%) as an orange solid.

Provenance & Evidence