HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous chloride dihydrate → 4-(Imidazo[1,2-a]pyridin-2-yl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | Imidazo(1,2-a)pyridine, 2-(p-nitrophenyl)- | HCID 201134 | — |
| Reactant | Dichloromethane ethylacetate | HCID 21226138 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(Imidazo[1,2-a]pyridin-2-yl)aniline | HCID 696936 | 76.5% |
Reaction Steps
Prepared as described in the Nitro Reduction section using 2-(4-nitrophenyl)imidazo[1,2-a]pyridine (0.216 g, 0.90 mmol) and tin (II) chloride dihydrate (1.02 g, 4.52 mmol) in EtOH (25 ml) to give the title compound (0.144 g, 76%) as a pale yellow solid after work-up and flash chromatography (9:1 EtOAc/DCM).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895313B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-fc3a2c82e0214ef6b0e19a48d062380a |
| Source note | uspto-grants-2014_11 |