HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline → 4-(dimethylamino)-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | — |
| Reactant | 4-(Dimethylamino)benzoyl chloride | HCID 4400782 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-(dimethylamino)-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | HCID 45137441 | 54.2% |
Reaction Steps
Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (70 mg, 0.314 mmol) and 4-dimethylaminobenzoyl chloride (58 mg, 0.314 mmol) in dry pyridine (5 ml) to give the title compound (63 mg, 54%) as a pale yellow solid after work-up and flash chromatography (20:1 DCM/MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895313B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-fdf45a17294b4b1198982c7a02dba115 |
| Source note | uspto-grants-2014_11 |