Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Stannous chloride dihydrate → 4-amino-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 반응물 | N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]-4-nitrobenzamide | HCID 58342125 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-amino-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | HCID 58342079 | 78.2% |
반응 단계
Prepared as described in the Nitro Reduction section using N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]-4-nitrobenzamide (0.10 g, 0.269 mmol) and tin (II) chloride dihydrate (0.30 g, 1.34 mmol) in EtOH (15 ml) to give the title compound (0.072 g, 78%) as a pale yellow solid after work-up and flash chromatography (15:1 DCM/MeOH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08895313B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-af024a3812dd4aceb714b0aece2e2005 |
| 출처 메모 | uspto-grants-2014_11 |