HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Anisoyl chloride → 4-methoxy-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Anisoyl chloride | HCID 7477 | — |
| Reactant | 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)aniline | HCID 821084 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-methoxy-N-[4-(6-methylimidazo[1,2-a]pyridin-2-yl)phenyl]benzamide | HCID 42737530 | 79.3% |
Reaction Steps
Prepared as described in the Amide Coupling section using 4-(6-methylimidazo[1,2-a]pyridin-2-yl)aniline (70 mg, 0.314 mmol) and 4-methoxybenzoyl chloride (54 mg, 0.314 mmol) in dry pyridine (5 ml) to give the title compound (89 mg, 79%) as a pale yellow solid after work-up and flash chromatography (15:1 DCM/MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895313B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f32acd5a5cf7436caa612378691cafef |
| Source note | uspto-grants-2014_11 |