4-Nitrobenzaldehyde → 6-Methyl-2-{4-[(E)-2-(4-nitrophenyl)ethenyl]phenyl}imidazo[1,2-a]pyridine

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Reaction Steps

Prepared as described in the Alkene Formation section using sodium hydride (60% dispersion in mineral oil, 7 mg, 0.307 mmol), diethyl[4-(6-methylimidazo[1,2-a]pyridin-2-yl)benzyl phosphonate (100 mg, 0.279 mmol) and 4-nitrobenzaldehyde (42 mg, 0.279 mmol) in THF (5 ml) to give the title compound (24 mg, 24%) as a yellow solid after work-up and flash chromatography (100:1 DCM/MeOH).

Provenance & Evidence