Thionyl Chloride → HCID 68278639, compound

HRID 339601Notes

Reaction equation

HRID 339601 reaction equation
S(Cl)(Cl)=[O:2].[O:5]=[C:6]1[CH:10]([C:11]([OH:13])=[O:12])[CH2:9][CH2:8][N:7]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[OH:2][C:10]1([C:11]([OH:13])=[O:12])[CH2:9][CH2:8][N:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:6]1=[O:5]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 30437622-Oxo-1-phenylpyrrolidine-3-carboxylic acid

Product 1

HCID 68278639HCID 68278639, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

Thionyl chloride (5.8 g) is added dropwise at 0° C. to a solution of 2-oxo-1-phenylpyrrolidine-3-carboxylic acid (5 g) in 5 ml of ethanol, and the mixture is stirred at 80° C. for 4 h.

Sources & evidence

ORD record
ord-e3d49f17d26d4795b8b5e8a683b75acd
Source dataset
uspto-grants-2014_11
Patent number
US08895535B2

Reaction notes

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