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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 339680Generated: October 26, 2026

tert-Butyl piperazine-1-carboxylate → Tert-butyl (1-(2-formylquinolin-8-yl)piperidin-4-yl)methylcarbamate

https://huagongshe.com/reaction/339680

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
ReactantTert-butyl (piperidin-4-ylmethyl)carbamateHCID 723429—
Reactant2-(7-(2-Methoxyethoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl trifluoromethane sulfonateHCID 86654341—
ProductTert-butyl (1-(2-formylquinolin-8-yl)piperidin-4-yl)methylcarbamateHCID 86654345—

Reaction Steps

Prepared as described in Example 1, Step H, substituting 8-bromoquinoline-2-carbaldehyde for 2-(7-(2-methoxyethoxy)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yl trifluoromethane sulfonate, and tert-butyl piperidin-4-ylmethylcarbamate for tert-butyl piperazine-1-carboxylate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08895550B2
Source datasetuspto-grants-2014_11
ORD IDord-23c2aa3a353b42d9b12e66f18f67609f
Source noteuspto-grants-2014_11