反应详情

8-Bromo-6-fluoroquinoline-2-carbaldehyde (100 mg, 0.39 mmol) and 1-(pyridin-2-yl)hydrazine (43 mg, 0.39 mmol) were dissolved in 15 mL of absolute EtOH, and heated to reflux for 2 hours, at which time all starting material had been consumed. The reaction was then cooled to ambient temperature, and the yellow/orange product was collected by filtration (wash EtOH), affording (100 mg, 73.6% yield) as a yellow solid. MS APCI (+) m/z 345.1 and 347 (M+1 of each Br isotope) detected.

1. temperatureheated
2. temperatureto reflux for 2 hours, at which time all starting material
3. customhad been consumed
4. filtrationthe yellow/orange product was collected by filtration (wash EtOH)
5. customaffording (100 mg, 73.6% yield) as a yellow solid