1,4-Dioxane → HCID 86654355, compound

Participants

Reaction Conditions

Reaction Steps

A slurry of SeO2 (0.869 g, 7.83 mmol) and 1,4-dioxane (20 mL) was warmed to 80° C. and then the product from Step B (2.3 g, 6.53 mmol) was added as a 1,4-dioxane solution (20 mL). The mixture was stirred at 80° C. for 32 hours. The mixture was cooled to ambient temperature and filtered through GF/F filter paper and the residual solid was washed with CH2Cl2. The filtrate was concentrated and purified by passing through a silica gel plug, eluting with 50% CH2Cl2/hexane to provide 2.14 g (89%) of the product as a yellow/orange solid.

Provenance & Evidence