Iodo benzene diacetate → HCID 67234839, compound

HRID 339698Notes

Reaction equation

HRID 339698 reaction equation
[Br:1][C:2]1[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH:20]=[N:21][NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)=[N:9]2)=[CH:4][CH:3]=1.C(O)(=O)C.C(O)(=O)C.IC1C=CC=CC=1>C(Cl)Cl>[N:22]1[N:21]=[C:20]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[C:11]([O:12][Si:13]([C:16]([CH3:19])([CH3:17])[CH3:18])([CH3:15])[CH3:14])[C:2]([Br:1])=[CH:3][CH:4]=3)[N:9]=2)[N:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=12

Participants

4

Reactant 2

HCID 12217721Iodo benzene diacetateHCID 67233679HCID 67233679, compound

Product 1

HCID 67234839HCID 67234839, compoundYield 97.7%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the product from Step D (2.95 g, 6.45 mmol) was added CH2Cl2 (60 mL). Iodobenzene diacetate (2.28 g, 7.09 mmol) was added and the mixture stirred at ambient temperature overnight. The mixture was concentrated and the product purified directly by column chromatography (1 to 8% MeOH/CH2Cl2) to afford 2.87 g (88%) of the product.

Workup

  1. concentrationThe mixture was concentrated
  2. customthe product purified directly by column chromatography (1 to 8% MeOH/CH2Cl2)

Sources & evidence

ORD record
ord-08b6b10c42f34c929999051fbe01191a
Source dataset
uspto-grants-2014_11
Patent number
US08895550B2

Reaction notes

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