HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 67319956, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 15110858 | HCID 15110858 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67319956 | HCID 67319956 | 105% |
Reaction Steps
The mixture of the 4-bromo-1,2-dimethyl-5-phenyl-1H-pyrrole-3-carboxylic acid (2.91 g, 9.91 mmol), NaOMe (11.3 mL, 25% wt in MeOH) and CuI (566 mg, 2.97 mmol) in MeOH (35 mL) was refluxed overnight. The reaction mixture was poured into 1M HCl solution (100 mL) and extracted with ethyl acetate (200 mL). The organic phase was dried over MgSO4 and evaporated under vacuum to provide the title compound (2.56 g, 10.4 mmol, 105%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895558B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-8831565cf91a43439588b2bde95d8cd6 |
| Source note | uspto-grants-2014_11 |