ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate → Ethyl 5-phenyl-1H-pyrrole-3-carboxylate

Participants

Reaction Steps

Ethyl 2-chloro-1-methyl-5-phenyl-1H-pyrrole-3-carboxylate (2.4 g, 9.1 mmol) and 10% Pd/C (100 mg) was dissolved in methanol (50 ml) at room temperature. The reaction mixture was hydrogenated for 6 hrs at room temperature and the resulting solution was filtered. After evaporated under reduced pressure, the residue was purified with normal phase preparative column chromatography to produce title compound (1.9g, 91%) as white solid.

Provenance & Evidence