反应详情

tert-Butyl 4-(quinolin-8-yl)piperazine-1-carboxylate (2.4 g, 7.66 mmol) was dissolved in methanol (50 ml) and SOCl2 was added to the solution dropwise at 0° C. The resulting solution was refluxed for 1 day and evaporated under reduced pressure. EtOAc (50 ml) was added to the residue and stirred for 2 hours to produce light yellow solid. The title compound was collected by filtration (1.7 g, 89%) as light yellow solid.

1. temperatureThe resulting solution was refluxed for 1 day
2. customevaporated under reduced pressure
3. additionEtOAc (50 ml) was added to the residue
4. customto produce light yellow solid
5. filtrationThe title compound was collected by filtration (1.7 g, 89%) as light yellow solid