Dichloromethane → HCID 58358800, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propyl)-4-methoxy-1,2-dimethyl-5-phenyl-1H-pyrrole-3-carboxamide (375 mg, 0.60 mmol) was added BBr3 (0.77 ml, 17% in DCM) slowly at 0° C. After stirring at 0° C. for 2˜3 hours, the mixture was quenched with saturated sodium bicarbonate solution and extracted with DCM (50 mL) MeI (2.13 mL, 34.2 mmol). The organic phase was dried over MgSO4 and evaporated under vacuum. The residue was further purified by prep HPLC (Gilson, C18 column) to provide title compound (73 mg, 20%).

Provenance & Evidence