HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycolic Acid → HCID 22003743, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycolic Acid | HCID 757 | — |
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Acetyl chloride, [[(1,1-dimethylethyl)dimethylsilyl]oxy]- | HCID 10932700 | — |
| Reactant | HCID 19793901 | HCID 19793901 | — |
| Product | HCID 22003743 | HCID 22003743 | — |
Reaction Steps
Scheme I shows the preparation of tert-butyldimethylsilyloxy acetyl chloride. Glycolic acid on reaction with TBDMS-Cl (tert-butyldimethylsilyloxy chloride) in the presence of imidazole provided O-tert-butyldimethylsilyloxy acetic acid, which on reaction with oxalyl chloride gave the desired acid chloride derivative.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895569B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f4bfa73632f44dbeb9cde3a57843e20e |
| Source note | uspto-grants-2014_11 |