反应详情

A solution of 9-(2-hydroxy-3-phenyl-propyl)-2-pyridin-4-yl-3-(3-trifluoromethyl-phenyl)-6,7,8,9-tetrahydro-pyrimido[1,2-a]pyrimidin-4-one (50 mg, 0.1 mmol) in CH2Cl2 (5 mL) was treated with the Dess Martin Periodinane (450 mg, 1.1 mmol). After the mixture was stirred at room temperature for 5 hr, the mixture was washed with NaHCO3 (aq). The organic residue was loaded to a silica column and eluted with 0-4% (2N NH3-MeOH)/CH2Cl2. The product (4) was collected as a yellow solid (35 mg, 70%). M+1 505.

1. washthe mixture was washed with NaHCO3 (aq)
2. washeluted with 0-4% (2N NH3-MeOH)/CH2Cl2
3. customThe product (4) was collected as a yellow solid (35 mg, 70%)