HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-Amino-3-(2,5-difluorophenyl)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | 2,5-Difluorobenzaldehyde | HCID 137663 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Amino-3-(2,5-difluorophenyl)propanoic acid | HCID 16412810 | — |
Reaction Steps
A solution of 2,5-difluorobenzaldehyde (5 g), malonic acid (3.66 g) and ammonium acetate (5.42 g) in ethanol (50 ml) was heated under reflux for six hours. The mixture was cooled and left to stand overnight. The crystals formed were filtered off and washed with ethanol (5 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08895547B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-6689b046683d40b2bf586448f5338a30 |
| Source note | uspto-grants-2014_11 |