Hydrochloric Acid → HCID 178431676, compound

Participants

Reaction Steps

To detach the protecting group, 40 mg of [5-(4-benzyloxyphenyl)-6,6-dimethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-1,4,3-oxathiazin-2-yl]-[(S)-3-(tert-butyldimethylsilanyloxy)-1-phenylpropyl]amine were dissolved in 5 ml of methanol and, after addition of 1 ml of 2 N hydrochloric acid, stirred at room temperature for 1 hour. The reaction solution was neutralized with 2 ml of 1 N aqueous sodium hydroxide solution and concentrated by rotary evaporation, and the residue was purified in a purification laboratory by means of preparative HPLC. The product-containing fractions were combined and lyophilized. This gave the product (19.7 mg) with a molecular weight of 494.6 g/mol (C27H30N2O5S); MS (ESI): m/e=495 (M+H+).

Provenance & Evidence