反应详情

A solution of t-butyldimethylsilyl chloride (8.53 g, 56.3 mmol, 1.3 eq), imidazole (7.38 g, 108.3 mmol, 2.5 eq) and 4-nitro-benzyl alcohol (6.64 g, 43.3 mmol, 1 eq) in anhydrous DMF (25 mL) was stirred at room temperature under a N2 atmosphere for 72 h. The reaction mixture was diluted with H2O (500 mL) and extracted with Etoac (4×100 mL). The combined organic extracts were washed with H2O (100 mL), satd NaCl(aq) (100 mL), dried (MgSO4) and evaporated in vacuo. The residue was triturated with n-hexane and filtered. The filtrate was evaporated in vacuo to give the product as a yellow oil which crystallised (11.02 g, 95%). 1H NMR (CDCl3) δ 8.2 (d, J=8.25 Hz, 2H), 7.47 (d, J=8.02 Hz, 2H), 4.8 (s, 2H), 0.96 (s, 9H), 0.12 (s, 6H). IR (neat) 2955, 2930, 1605 and 1522 cm−1. HRMS m/z calcd for C13H22NO3 Si 268.1369 (M+H), found 268.1376

1. extractionextracted with Etoac (4×100 mL)
2. washThe combined organic extracts were washed with H2O (100 mL), satd NaCl(aq) (100 mL)
3. dry with materialdried (MgSO4)
4. customevaporated in vacuo
5. customThe residue was triturated with n-hexane
6. filtrationfiltered
7. customThe filtrate was evaporated in vacuo